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Stressing the other paraventricular nucleus

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Often overlooked, the paraventricular nucleus of the thalamus is a stress-sensitive region in the midline thalamus essential for stress-induced adaptations. Using cutting edge in vivo monitoring approaches, Beas, Wright et al. identify a circuit by which stress disinhibits the midline thalamus through dopaminergic modulation arising from the locus coeruleus.

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Fig. 1: Translation of stress to motivation circuitry.

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Authors and Affiliations

  1. Department of Psychological & Brain Sciences, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD, USA

    Kurt M. Fraser & Patricia H. Janak

  2. The Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA

    Patricia H. Janak

  3. Kavli Neuroscience Discovery Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA

    Patricia H. Janak

Authors
  1. Kurt M. Fraser
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  2. Patricia H. Janak
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Correspondence to Kurt M. Fraser or Patricia H. Janak.

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The authors declare no competing interests.

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Fraser, K.M., Janak, P.H. Stressing the other paraventricular nucleus. Nat Neurosci 21, 901–902 (2018). https://doi.org/10.1038/s41593-018-0178-1

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