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SYNAPTIC PLASTICITY

Synaptic homeostasis: quality vs. quantity

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Synaptic connections adapt homeostatically to changes in experience to maintain optimal circuit function. A study demonstrates that different forms of synaptic homeostasis respond to distinct aspects of circuit activity, suggesting that neurons can gauge and adapt to the both the quality and quantity of circuit activity.

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Fig. 1: Working model depicting the relationship of visual experience, neural circuit activity and two forms of homeostatic plasticity indicated by the findings of Bridi et al.3.

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Authors and Affiliations

  1. Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX, USA

    Kimberly M. Huber

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  1. Kimberly M. Huber
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Correspondence to Kimberly M. Huber.

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The author declares no competing interests.

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Huber, K.M. Synaptic homeostasis: quality vs. quantity. Nat Neurosci 21, 774–776 (2018). https://doi.org/10.1038/s41593-018-0159-4

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