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Using machine learning to predict the structure of proteins that bind to DNA and RNA

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We developed a machine learning model, RoseTTAFoldNA, that can predict the structures of protein–DNA and protein–RNA complexes. Our model is capable of predicting accurate structures of protein families for which structural information is unknown.

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Fig. 1: Example predictions of a protein–RNA and protein–DNA complex.

References

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This is a summary of: Baek, M. et al. Accurate prediction of protein–nucleic acid complexes using RoseTTAFoldNA. Nat. Methods https://doi.org/10.1038/s41592-023-02086-5 (2023).

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Using machine learning to predict the structure of proteins that bind to DNA and RNA. Nat Methods 21, 22–23 (2024). https://doi.org/10.1038/s41592-023-02088-3

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