CryoREAD automatically builds DNA–RNA atomic structure from cryo-EM maps. Backbone accuracy is typically >85% and the method is applicable for maps with RNA-only, DNA-only and DNA–RNA–protein complex structures. CryoREAD uses deep learning to identify structure information and subsequently construct the 3D structure of nucleic acids.
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This is a summary of: Wang, X. et al. CryoREAD: de novo structure modeling for nucleic acids in cryo-EM maps using deep learning. Nat. Methods https://doi.org/10.1038/s41592-023-02032-5 (2023).
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CryoREAD provides fully automated DNA–RNA structure modeling for cryo-EM maps. Nat Methods 20, 1637–1638 (2023). https://doi.org/10.1038/s41592-023-02033-4
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DOI: https://doi.org/10.1038/s41592-023-02033-4
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