Recently proposed computational approaches explore casual links between chromatin and transcriptional changes that are provided by single-cell multimodal sequencing to bridge the knowledge gap in transcriptional regulatory control.
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Acknowledgements
I thank C. Kuppe and S. Hayat (RWTH Aachen Medical Faculty) for comments and suggestions. This work was supported by the German Research Foundation (DFG) and the E:MED Fibromap Consortia from the German Ministry of Education and Science (BMBF).
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Costa, I.G. Dissecting gene regulation with multimodal sequencing. Nat Methods 20, 1282–1284 (2023). https://doi.org/10.1038/s41592-023-01957-1
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DOI: https://doi.org/10.1038/s41592-023-01957-1
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