Skip to main content

Advertisement

SpringerLink
Log in

Optogenetics

Controlling cellular activities with light

  • News & Views
  • Published:

From Nature Methods

View current issue Submit your manuscript

  • 5 Altmetric

New red–green optogenetic dimerizers enable the switching on and off of gene expression with high spatiotemporal precision.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: BICYCL optogenetic systems for controlling gene expression.

References

  1. Deisseroth, K. et al. J. Neurosci. 26, 10380–10386 (2006).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Rost, B. R., Schneider-Warme, F., Schmitz, D. & Hegemann, P. Neuron 96, 572–603 (2017).

    Article  CAS  PubMed  Google Scholar 

  3. Klewer, L. & Wu, Y. W. Chemistry 25, 12452–12463 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Levskaya, A., Weiner, O. D., Lim, W. A. & Voigt, C. A. Nature 461, 997–1001 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Shimizu-Sato, S., Huq, E., Tepperman, J. M. & Quail, P. H. Nat. Biotechnol. 20, 1041–1044 (2002).

    Article  CAS  PubMed  Google Scholar 

  6. Blain-Hartung, M. et al. J. Biol. Chem. 293, 8473–8483 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Ong, N. T. & Tabor, J. J. ChemBioChem. 19, 1255–1258 (2018).

    Article  CAS  PubMed  Google Scholar 

  8. Jang, J. et al. Nat. Methods https://doi.org/10.1038/s41592-023-01764-8 (2023).

  9. Müller, K. et al. Chem. Commun. 49, 8970–8972 (2013).

    Article  Google Scholar 

  10. Kaberniuk, A. A., Shemetov, A. A. & Verkhusha, V. V. Nat. Methods 13, 591–597 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Chen, X. & Wu, Y. W. Angew. Chem. Int. Ed. 57, 6796–6799 (2018).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

Y.-W.W. is supported by the European Research Council (ChemBioAP), Vetenskapsrådet (nr 2018-04585), the Knut and Alice Wallenberg Foundation and the Göran Gustafsson Foundation for Research in Natural Sciences and Medicine. The author thanks colleagues at Wu laboratory for discussion, and acknowledges D. Corkery for proofreading of the manuscript.

Author information

Authors and Affiliations

  1. Department of Chemistry, Umeå University, Umeå, Sweden

    Yao-Wen Wu

  2. Umeå Centre for Microbial Research, Umeå University, Umeå, Sweden

    Yao-Wen Wu

Authors
  1. Yao-Wen Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yao-Wen Wu.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wu, YW. Controlling cellular activities with light. Nat Methods 20, 357–358 (2023). https://doi.org/10.1038/s41592-022-01745-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41592-022-01745-3

  • Springer Nature America, Inc.

Search

Navigation