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Controlling protein function with HCV protease

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Two methods for controlling protein activities with small molecules provide a general solution to a long-standing challenge in mammalian synthetic biology.

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Fig. 1: In LInC and StaPLs, a linker using HCV protease and its cognate recognition sequence is installed between a protein of interest and a regulatory domain.

Marina Corral Spence/Springer Nature

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Correspondence to Bryan C. Dickinson.

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Dickinson, B.C. Controlling protein function with HCV protease. Nat Methods 15, 489–490 (2018). https://doi.org/10.1038/s41592-018-0043-x

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