A pilot study suggests that the bispecific T cell engager blinatumomab may provide a new therapy for patients with refractory rheumatoid arthritis; larger studies and deep phenotyping will be crucial to thoroughly evaluate and optimize this approach.
References
Edwards, J. C. W. et al. New Engl. J. Med. 350, 2572–2581 (2004).
Buch, M. H., Eyre, S. & McGonagle, D. Nat. Rev. Rheumatol. 17, 17–33 (2021).
Bykerk, V. P. Nat. Rev. Rheumatol. 14, 191–192 (2018).
Bucci, L. et al. Nat. Med. https://doi.org/10.1038/s41591-024-02964-1 (2024).
Teng, Y. K. O. et al. Arthritis Rheum. 56, 3909–3918 (2007).
Kavanaugh, A. et al. Ann. Rheum. Dis. 67, 402–408 (2008).
Kantarjian, H. et al. New Engl. J. Med. 376, 836–847 (2017).
Topp, M. S. et al. J. Clin. Oncol. 29, 2493–2498 (2011).
Isaacs, J. D. et al. Ann. Rheum. Dis. 72, 329–336 (2013).
Rivellese, F. et al. Nat. Med. 28, 1256–1268 (2022).
Mauri, C. & Menon, M. J. Clin. Invest. 127, 772–779 (2017).
Mackensen, A. et al. Nat. Med. 28, 2124–2132 (2022).
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L.T. reports consultant or speaker fees from GSK and AbbVie; and research funding from Sanofi. B.K. reports consultant or speaker fees from Abbvie, Eli Lilly, Galapagos, Janssen, Novartis, Pfizer and UCB. F.H. reports consultant or speaker fees from Galapagos, Roche and Abbvie.
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Humby, F., Kirkham, B. & Taams, L. BiTE therapy for rheumatoid arthritis. Nat Med (2024). https://doi.org/10.1038/s41591-024-02982-z
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DOI: https://doi.org/10.1038/s41591-024-02982-z
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