A phase 1 trial of an IRAK4-targeted protein degrader in patients with chronic inflammatory skin diseases hits an important milestone for the safe application of this drug class beyond oncology.
References
Burslem, G. M. & Crews, C. M. Cell 181, 102–114 (2020).
Chirnomas, D., Hornberger, K. R. & Crews, C. M. Nat. Rev. Clin. Oncol. 20, 265–278 (2023).
Ackerman, L. Nat. Med. https://doi.org/10.1038/s41591-023-02635-7 (2023).
McElroy, W. T. Expert Opin. Ther. Pat. 29, 243–259 (2019).
Danto, S. I. et al. Arthritis Res. Ther. 21, 269 (2019).
Matyskiela, M. E. et al. Nat. Chem. Biol. 14, 981–987 (2018).
Donovan, K. A. et al. Elife 7, e38430 (2018).
Ghobrial, I. M. & Rajkumar, S. V. J. Support. Oncol. 1, 194–205 (2003).
Volak, L. P. et al. Drug Metab. Dispos. 51, 792–803 (2023).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
F.M.F. is a scientific co-founder and equity holder in Proximity Therapeutics, was recently a scientific advisory board (SAB) member for Triana Biomedicines, and is or recently was a consultant or received speaking honoraria from Eli Lilly and Co., RA Capital, Tocris BioTechne, Johnson & Johnson Innovative Medicine and Plexium Inc. The Ferguson lab receives or has received research funding from Ono Pharmaceutical Co. Ltd and Merck & Co.
Rights and permissions
About this article
Cite this article
Ferguson, F.M. PROTACs reach clinical development in inflammatory skin disease. Nat Med 29, 3006–3007 (2023). https://doi.org/10.1038/s41591-023-02622-y
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41591-023-02622-y
- Springer Nature America, Inc.