Two modelling studies offer compelling evidence that less-than-perfect adherence to HIV pre-exposure prophylaxis can still provide reasonable protection for cisgender women — providing optimism for a more person-centered approach and lower discontinuation rates.
References
UNAIDS. UNAIDS Data 2022 https://go.nature.com/46orpSc (2022).
Zhang, J. et al. Lancet HIV 9, e254–e268 (2022).
Celum, C. L. et al. J. Int. AIDS Soc. 22, e25298 (2019).
Molina, J. M. et al. Lancet HIV 9, e554–e562 (2022).
Goldwirt, L. et al. J. Antimicrob. Chemother. 76, 2675–2680 (2021).
Velloza, J. et al. Lancet HIV 9, e680–e689 (2022).
Moore, M. et al. Nat. Med. https://doi.org/10.1038/s41591-023-02564-5 (2023).
Zhang, L. et al. Nat. Med. https://doi.org/10.1038/s41591-023-02615-x (2023).
Adamson, B., Dimitrov, D., Devine, B. & Barnabas, R. Pharmacoecon Open 1, 1–12 (2017).
Marrazzo, J. et al. in Conference for Retroviruses and Opportunistic Infections (CROI) https://www.natap.org/2023/CROI/croi_30.htm (2023).
WHO. Differentiated and Simplified HIV Pre-exposure Prophylaxis for HIV Prevention technical brief; https://www.who.int/publications/i/item/9789240053694 (2022).
Phillips, A. N. et al. J. Infect. Dis. 223, 1345–1355 (2021).
Acknowledgements
M.S. is a National Institute for Health and Care Research (NIHR) global research professor (NIHR 301634) and receives funding from the Bill and Melinda Gates Foundation (BMGF) (INV-033650); US National Institute of Health (NIH) (5R01MH114560-03); and the Wellcome Trust (082384/Z/07/Z). F.C. and M.S. receive funding from Wellcome Trust (214280/z/18/Z). F.C. also receives funding from BMGF (OPP1136774). N.C. is supported by a NIHR and Wellcome Trust International Training fellowship (224309/Z/21/Z).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Rights and permissions
About this article
Cite this article
Shahmanesh, M., Chimbindi, N. & Cowan, F.M. Person-centered HIV PrEP for cisgender women. Nat Med 29, 2707–2708 (2023). https://doi.org/10.1038/s41591-023-02618-8
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41591-023-02618-8
- Springer Nature America, Inc.