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Determining the longevity and dynamics of HIV-1 neutralizing activity

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The induction of neutralizing antibodies is the main goal of an HIV-1 vaccine, although data on the longevity of such antibodies is lacking. By tracking neutralizing antibodies in a large cohort of individuals infected with HIV-1 who had varying viral loads, we show that the HIV-1 neutralization response can last for several years even at low antigen levels.

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Fig. 1: Durability of HIV-1 neutralization is determined by antigen exposure.

References

  1. Gruell, H. & Schommers, P. Broadly neutralizing antibodies against HIV-1 and concepts for application. Curr. Opin. Virol. 54, 101211 (2022). This review summarizes the most recent developments in the HIV-1 bNAb field.

    Article  CAS  PubMed  Google Scholar 

  2. Corey, L. et al. Two randomized trials of neutralizing antibodies to prevent HIV-1 acquisition. N. Engl. J. Med. 384, 1003–1014 (2021). This paper reports the results of the Antibody Mediated Protection (AMP) trials.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Haynes, B. F. et al. Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies. Nat. Rev. Immunol. 23, 142–158 (2023). A review that summarizes current efforts in developing bNAb-inducing vaccines.

    Article  CAS  PubMed  Google Scholar 

  4. Landais, E. & Moore, P. Development of broadly neutralizing antibodies in HIV-1 infected elite neutralizers. Retrovirology 15, 61 (2018). An article that reviews our current understanding of the development of neutralizing serum responses in individuals infected with HIV-1.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Schommers, P. et al. Restriction of HIV-1 escape by a highly broad and potent neutralizing antibody. Cell 180, 471–489.e422 (2020). This paper reports the identification of the bNAb 1-18 from elite neutralizer IDC561.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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This is a summary of: Schommers, P. et al. Dynamics and durability of HIV-1 neutralization are determined by viral replication. Nat. Med. https://doi.org/10.1038/s41591-023-02582-3 (2023).

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Determining the longevity and dynamics of HIV-1 neutralizing activity. Nat Med 29, 2720–2721 (2023). https://doi.org/10.1038/s41591-023-02592-1

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  • DOI: https://doi.org/10.1038/s41591-023-02592-1

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