Cost-effective fluid biomarkers for tau aggregate pathology would improve the diagnostic and prognostic work-up of Alzheimer’s disease and facilitate the discovery of anti-tau therapies. We identified MTBR-tau243 as a specific marker for tau aggregate pathology that could be implemented in clinical practice and trials.
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References
Hansson, O. Biomarkers for neurodegenerative diseases. Nat. Med. 27, 954–963 (2021). A review of AD and other neurodegenerative diseases, with a focus on biomarkers currently available.
Ossenkoppele, R. et al. Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline. Nat. Med. 28, 2381–2387 (2022). A paper showing that tau pathology is a much stronger predictor of cognitive decline than Aβ, even during the earliest stages of the disease.
Ossenkoppele, R., van der Kant, R. & Hansson, O. Tau biomarkers in Alzheimer’s disease: towards implementation in clinical practice and trials. Lancet Neurol. 21, 726–734 (2022). A review of the currently available markers of tau pathology, and recent anti-tau trials in AD.
Salvadó, G. et al. Specific associations between plasma biomarkers and postmortem amyloid plaque and tau tangle loads. EMBO Mol. Med. 15, e2463 (2023). A neuropathology-based study showing that there are not any fluid biomarkers specific for tau aggregate pathology available at present.
Horie, K., Barthelemy, N. R., Sato, C. & Bateman, R. J. CSF tau microtubule binding region identifies tau tangle and clinical stages of Alzheimer’s disease. Brain 144, 515–527 (2021). A small pilot study showing that MTBR-tau243 can be detected in CSF and can be associated with tau tangles.
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This is a summary of: Horie, K. et al. CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer’s disease. Nat. Med. https://doi.org/10.1038/s41591-023-02443-z (2023).
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A fluid biomarker accurately detects tau aggregate pathology in Alzheimer’s disease. Nat Med 29, 1912–1913 (2023). https://doi.org/10.1038/s41591-023-02468-4
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DOI: https://doi.org/10.1038/s41591-023-02468-4
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