We performed multi-ancestry genome-wide meta-analyses of preeclampsia/eclampsia and gestational hypertension, identifying 12 susceptibility loci associated with one or both conditions. These analyses enabled the derivation of genome-wide polygenic risk scores, which predicted the development of these hypertensive pregnancy complications in independent cohorts, independent of clinical risk factors.
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References
Rana, S., Lemoine, E., Granger, J. & Karumanchi, S. A. Preeclampsia. Circ. Res. 124, 1094–1112 (2019). A review article that summarizes the current understanding of the pathophysiology of preeclampsia.
Davidson, K. W. et al. Aspirin use to prevent preeclampsia and related morbidity and mortality: US Preventive Services Task Force recommendation statement. JAMA. 326, 1186–1191 (2021). This recommendation statement summarizes high-level and moderate-level risk factors for preeclampsia, and evidence for use of low-dose aspirin for preeclampsia prevention.
Steinthorsdottir, V. et al. Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women. Nat. Commun. 11, 5976 (2020). This article presents the largest, to our knowledge, existing GWAS of preeclampsia.
Honigberg, M. C. et al. Genetic variation in cardiometabolic traits and medication targets and the risk of hypertensive disorders of pregnancy. Circulation. 142, 711–713 (2020). This paper demonstrates that blood pressure polygenic risk predicts development of HDPs.
Goetze, J. P. et al. Cardiac natriuretic peptides. Nat. Rev. Cardiol. 17, 698–717 (2020). A review article that summarizes the physiology and clinical utility of the cardiac natriuretic peptides.
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This is a summary of: Honigberg, M. C. et al. Polygenic prediction of preeclampsia and gestational hypertension. Nat. Med. https://doi.org/10.1038/s41591-023-02374-9 (2023).
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Uncovering genetic correlates and advancing prediction of hypertension in pregnancy. Nat Med 29, 1334–1335 (2023). https://doi.org/10.1038/s41591-023-02394-5
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DOI: https://doi.org/10.1038/s41591-023-02394-5
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