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Postoperative circulating tumor DNA could guide CRC adjuvant treatment

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The large, ongoing CIRCULATE-Japan trial is investigating the role of circulating tumor DNA (ctDNA)-based molecular residual disease testing in patients with resectable colorectal cancer after radical surgery. An interim analysis of GALAXY, a prospective, observational arm of CIRCULATE-Japan, establishes ctDNA as a prognostic and predictive biomarker.

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Fig. 1: ctDNA-based molecular residual disease testing is predictive of response to adjuvant chemotherapy in surgically treated patients with CRC.

References

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Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Kotani, D. A. et al. Molecular residual disease and efficacy of adjuvant chemotherapy in patients with colorectal cancer. Nat. Med. https://doi.org/10.1038/s41591-022-02115-4 (2023).

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Postoperative circulating tumor DNA could guide CRC adjuvant treatment. Nat Med 29, 39–40 (2023). https://doi.org/10.1038/s41591-022-02119-0

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  • DOI: https://doi.org/10.1038/s41591-022-02119-0

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