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Musculoskeletal disorders

Targeted therapy for osteoarthritis: progress and pitfalls

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Osteoarthritis is highly heterogeneous, so effective therapies will need to target clearly defined molecular endotypes, restore mechanical joint function and reduce pain; thus, a ‘one-size-fits-all’ approach is unlikely to succeed.

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Fig. 1: Selective OA therapeutic strategies in development.

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Acknowledgements

This work was supported by the German Research Society (DFG; grant number GR 1301/22-1, assigned to S.G.).

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Authors and Affiliations

  1. Experimental Orthopaedics, Centre for Medical Biotechnology (ZMB), University of Regensburg, Regensburg, Germany

    Nicole Schäfer & Susanne Grässel

  2. Department of Orthopaedic Surgery, University of Regensburg, Regensburg, Germany

    Susanne Grässel

Authors
  1. Nicole Schäfer
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  2. Susanne Grässel
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Corresponding author

Correspondence to Susanne Grässel.

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The authors declare no competing interests.

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Schäfer, N., Grässel, S. Targeted therapy for osteoarthritis: progress and pitfalls. Nat Med 28, 2473–2475 (2022). https://doi.org/10.1038/s41591-022-02057-x

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