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Visualizing heterogeneity in type 2 diabetes phenotype, outcome and drug response

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Phenotypic heterogeneity in type 2 diabetes (T2D) was visualized by non-linear dimensionality reduction in a cohort of over 23,000 people. Variation in the T2D phenotype mapped to variation in drug response, risk of disease complications and underlying genetic architecture.

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Fig. 1: Heterogeneity of the T2D phenotype at diagnosis.

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This is a summary of: Thakarakkattil Narayanan Nair, A. et al. Heterogeneity in phenotype, disease progression and drug response in type 2 diabetes. Nat. Med. https://doi.org/10.1038/s41591-022-01790-7 (2022).

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Visualizing heterogeneity in type 2 diabetes phenotype, outcome and drug response. Nat Med 28, 909–910 (2022). https://doi.org/10.1038/s41591-022-01791-6

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