Many newly approved cancer therapeutics offer limited clinical benefits yet are still prescribed to patients. A common-sense revolution in oncology would prioritize treatments that meaningfully improve survival and quality of life.
References
Gyawali, B. et al. ESMO Open 6, 100117 (2021).
Abola, M. V. & Prasad, V. JAMA Oncol. 2, 139–141 (2016).
Abola, M. V. & Prasad, V. Mayo Clin. Proc. 91, 1668–1670 (2016).
Del Paggio, J. C. et al. JAMA Oncol. 7, 728–734 (2021).
Sharma, S. et al. J. Natl. Compr. Canc. Netw. https://doi.org/10.6004/jnccn.2021.7016 (2020).
Del Paggio, J. C. et al. Lancet Oncol. 18, 887–894 (2017).
Del Paggio, J. C. et al. Ann. Oncol. 28, 157–162 (2017).
Gyawali, B. et al. Lancet Oncol. 19, 288–290 (2018).
Gyawali, B. et al. Nat. Cancer 1, 142–145 (2020).
Raphael, M. J. et al. Nat. Rev. Clin. Oncol. 17, 271–272 (2020).
Booth, C. M. et al. Nat. Rev. Clin. Oncol. 16, 312–325 (2019).
Gyawali, B. et al. Br. Med. J. 374, n1959 (2021).
Gyawali, B. et al. Am. Soc. Clin. Oncol. Educ. Book 39, 374–387 (2019).
Hoffmann, T. C. & Del Mar, C. JAMA Intern. Med. 177, 407–419 (2017).
Smith, T. J. & Hillner, B. E. N. Engl. J. Med. 364, 2060–2065 (2011).
Weeks, J. C. et al. N. Engl. J. Med. 367, 1616–1625 (2012).
Hoffmann, T. C. & Del Mar, C. JAMA Intern. Med. 175, 274–286 (2015).
Fundytus, A. et al. JAMA Oncol. 7, 1757–1758 (2021).
Schnipper, L. E. et al. J. Clin. Oncol. 30, 1715–1724 (2012).
Schnipper, L. E. et al. J. Clin. Oncol. 33, 2563–2577 (2015).
Cherny, N. I. et al. Ann. Oncol. 28, 2340–2366 (2017).
Acknowledgements
We acknowledge E. Eisenhauer (Queen’s University, Kingston, Canada) and I. Tannock (Princess Margaret Cancer Centre, Toronto, Canada) for helpful comments on an earlier draft of the manuscript. C.M.B. is supported as the Canada Research Chair in Population Cancer Care. B.G. receives salary support from the Ontario Institute for Cancer Research funded by the government of Ontario.
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B.G. and C.M.B. contributed equally to the manuscript, including its conception, writing and editing.
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B.G. has received consulting fees from Vivio Health.
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Gyawali, B., Booth, C.M. Cancer treatments should benefit patients: a common-sense revolution in oncology. Nat Med 28, 617–620 (2022). https://doi.org/10.1038/s41591-021-01662-6
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DOI: https://doi.org/10.1038/s41591-021-01662-6
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