A new trial suggests that pirfenidone, an approved treatment for idiopathic pulmonary fibrosis, may also reduce myocardial fibrosis in patients with heart failure who have a preserved left ventricular ejection fraction.
References
Lewis, G. A. et al. Nat. Med. https://doi.org/10.1038/s41591-021-01452-0 (2021).
Cleland, J. G. F. et al. Eur. Heart J. 42, 2331–2343 (2021).
Pellicori, P. et al. Eur. J. Heart Fail. https://doi.org/10.1002/ejhf.2220 (2021).
Pellicori, P. et al. Eur. J. Heart Fail. 22, 1711–1723 (2020).
Pellicori, P. et al. Cardiovasc. Res. 116, 91–100 (2020).
Cleland, J. G. F. et al. Eur. Heart J. 39, 26–35 (2018).
Cleland, J. G. F. et al. Eur. Heart J. 42, 684–696 (2020).
Gonzalez, A., Schelbert, E. B., Diez, J. & Butler, J. J. Am. Coll. Cardiol. 71, 1696–1706 (2018).
Aimo, A. et al. Pharmacol. Res. 155, 104694 (2020).
Lopez, B. et al. J. Am. Coll. Cardiol. 67, 251–260 (2016).
Lopez, B. et al. Nat. Rev. Cardiol. 18, 479–498 (2021).
Mason, T. et al. JACC Cardiovasc. Imaging 14, 1164–1173 (2021).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
J.G.F.C. has received research funding from Torrent Pharmaceuticals, which has an advanced glycation-end-product breaker in development.
Rights and permissions
About this article
Cite this article
Cleland, J.G.F., Pellicori, P. & González, A. A novel treatment for heart failure targets myocardial fibrosis. Nat Med 27, 1343–1344 (2021). https://doi.org/10.1038/s41591-021-01457-9
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41591-021-01457-9
- Springer Nature America, Inc.
This article is cited by
-
Computational screen for sex-specific drug effects in a cardiac fibroblast signaling network model
Scientific Reports (2023)