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Context matters in CAR T cell tonic signaling

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Unexpected clinical results unearth a new facet in CAR design that could facilitate the development of more-effective CAR T cell therapies.

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Authors and Affiliations

  1. Early Clinical Development, Hematology/Oncology and Cell Therapy, Bristol Myers Squibb, Redwood City, CA, USA

    Kristen Hege

  2. Division of Hematology/Oncology, University of California San Francisco, San Francisco, CA, USA

    Kristen Hege

Authors
  1. Kristen Hege
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Correspondence to Kristen Hege.

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Competing interests

K.H. is an employee and stockholder of Bristol Myers Squibb; an independent board of directors member and stockholder of Mersana Therapeutics; and a volunteer faculty member in the Division of Hematology/Oncology at the University of California San Francisco.

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Hege, K. Context matters in CAR T cell tonic signaling. Nat Med 27, 763–764 (2021). https://doi.org/10.1038/s41591-021-01340-7

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