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EHRs could clarify drug safety in pregnant people

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Testing drug safety in people who are pregnant remains a wicked problem, but in the transition toward big data and machine learning, target trials could afford a viable alternative to randomized, controlled trials.

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Acknowledgements

We thank A. L. Beam for insights on target trials.

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Authors and Affiliations

  1. Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA

    Anup P. Challa, Robert R. Lavieri & Jill M. Pulley

  2. Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA

    Anup P. Challa & Ethan S. Lippmann

  3. Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

    Jeffery A. Goldstein

  4. Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA

    Lisa Bastarache

  5. Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA

    David M. Aronoff

  6. Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA

    David M. Aronoff

  7. Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA

    David M. Aronoff

Authors
  1. Anup P. Challa
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  2. Robert R. Lavieri
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  3. Ethan S. Lippmann
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  4. Jeffery A. Goldstein
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  5. Lisa Bastarache
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  6. Jill M. Pulley
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  7. David M. Aronoff
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Contributions

A.P.C., R.R.L., E.S.L., J.A.G. and L.B. drafted this Comment, and J.M.P. and D.M.A. reviewed it for completeness and technical accuracy.

Corresponding author

Correspondence to Anup P. Challa.

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The authors declare no competing interests.

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Challa, A.P., Lavieri, R.R., Lippmann, E.S. et al. EHRs could clarify drug safety in pregnant people. Nat Med 26, 820–821 (2020). https://doi.org/10.1038/s41591-020-0925-1

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  • DOI: https://doi.org/10.1038/s41591-020-0925-1

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