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NEURODEGENERATION

An Alzheimer’s-disease-protective APOE mutation

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Homozygous APOE3-Christchurch (R136S) mutation protects a presenilin 1 (PSEN1) mutation carrier from developing Alzheimer’s disease until her seventies.

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Fig. 1: Effects of APOE3-R136S on Aβ and tau pathologies, neurodegeneration and cognition in PSEN1 mutation carriers, with potential underlying mechanisms.

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Authors and Affiliations

  1. Gladstone Institute of Neurological Disease, San Francisco, CA, USA

    Kelly A. Zalocusky, Maxine R. Nelson & Yadong Huang

  2. Department of Neurology, University of California, San Francisco, San Francisco, CA, USA

    Kelly A. Zalocusky & Yadong Huang

  3. Biomedical Sciences Program, University of California, San Francisco, San Francisco, CA, USA

    Maxine R. Nelson & Yadong Huang

Authors
  1. Kelly A. Zalocusky
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  2. Maxine R. Nelson
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  3. Yadong Huang
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Corresponding author

Correspondence to Yadong Huang.

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Competing interests

Y. H. is a cofounder and scientific advisory board member of E-Scape Bio, Inc. and GABAeron, Inc. The other authors declare no competing financial interests.

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Zalocusky, K.A., Nelson, M.R. & Huang, Y. An Alzheimer’s-disease-protective APOE mutation. Nat Med 25, 1648–1649 (2019). https://doi.org/10.1038/s41591-019-0634-9

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