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Cardiovascular disease

A protective smooth muscle cell transition in atherosclerosis

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TCF21, a gene associated with coronary heart disease, promotes plaque stability and reduces clinical events by enhancing smooth muscle cell phenotype modulation into “fibromyocytes” in atherosclerosis.

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Fig. 1: The role of TCF21 in atherosclerosis.

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Correspondence to Muredach P. Reilly.

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Pan, H., Reilly, M.P. A protective smooth muscle cell transition in atherosclerosis. Nat Med 25, 1194–1195 (2019). https://doi.org/10.1038/s41591-019-0541-0

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