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Divergent effects of lipids on stroke

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A large study provides causal evidence of the opposing effects of plasma low-density lipoprotein (LDL) levels on ischemic and hemorrhagic stroke in a Chinese population and suggests there is a a net benefit associated with LDL lowering.

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Fig. 1: The link between plasma LDL and stroke.

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Authors and Affiliations

  1. Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA

    Neal S. Parikh & Mitchell S. V. Elkind

  2. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA

    Mitchell S. V. Elkind

Authors
  1. Neal S. Parikh
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  2. Mitchell S. V. Elkind
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Correspondence to Mitchell S. V. Elkind.

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Competing interests

M.S.V.E. discloses receiving personal compensation for serving as an expert witness for Merck/Organon and Auxilium; honoraria for writing chapters on stroke for UpToDate; and research support but no personal compensation for a federally funded clinical trial related to stroke prevention from both the BMS-Pfizer Alliance for Eliquis and Roche; and serving as an unpaid national board member of the American Heart Association. N.S.P. has no competing interests.

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Parikh, N.S., Elkind, M.S.V. Divergent effects of lipids on stroke. Nat Med 25, 543–544 (2019). https://doi.org/10.1038/s41591-019-0413-7

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