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DISEASE GENETICS

Linking brain tumors and epileptic seizures

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Mutationally activated BRAF-V600E influences the behavior of different types of cells in the brain and leads to promotion of seizures as well as brain tumors, indicating how both can be pharmacologically targeted in the clinic.

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Fig. 1: The role of BRAF-V600E signaling and REST in GG-associated intractable epilepsy.

References

  1. López González, F. J. et al. Neurologia 30, 439–446 (2015).

    Article  Google Scholar 

  2. Chen, D. Y., Chen, C. C., Crawford, J. R. & Wang, S. G. J. Neurooncol. 139, 13–21 (2018).

    Article  Google Scholar 

  3. Lim, J. S. et al. Am. J. Hum. Genet. 100, 454–472 (2017).

    Article  CAS  Google Scholar 

  4. Krueger, D. A. et al. Neurology 87, 2408–2415 (2016).

    Article  CAS  Google Scholar 

  5. Koh, H. Y. et al. Nat. Med. https://doi.org/10.1038/s41591-018-0172-x (2018).

    Article  CAS  Google Scholar 

  6. Martinoni, M. et al. J. Clin. Neurosci. 22, 1250–1253 (2015).

    Article  CAS  Google Scholar 

  7. Marucci, G. et al. Ann. Clin. Transl. Neurol. 1, 130–134 (2014).

    Article  CAS  Google Scholar 

  8. Lee, J. H. et al. Nature 560, 243–247 (2018).

    Article  CAS  Google Scholar 

  9. Goldberg, E. M. & Coulter, D. A. Nat. Rev. Neurosci. 14, 337–349 (2013).

    Article  CAS  Google Scholar 

  10. Hertzman Johansson, C. & Egyhazi Brage, S. Pharmacol. Ther. 142, 176–182 (2014).

    Article  CAS  Google Scholar 

  11. Mittapalli, R. K., Vaidhyanathan, S., Dudek, A. Z. & Elmquist, W. F. J. Pharmacol. Exp. Ther. 344, 655–664 (2013).

    Article  CAS  Google Scholar 

  12. Kieran, M. W. et al. J. Clin. Oncol. 33, 10004 (2015).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children’s Hospital Colorado and University of Colorado, Denver, CO, USA

    Jean M. Mulcahy Levy

  2. Huntsman Cancer Institute and Department of Dermatology, University of Utah, Salt Lake City, UT, USA

    Martin McMahon

Authors
  1. Jean M. Mulcahy Levy
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  2. Martin McMahon
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Corresponding authors

Correspondence to Jean M. Mulcahy Levy or Martin McMahon.

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The authors declare no competing interests.

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Mulcahy Levy, J.M., McMahon, M. Linking brain tumors and epileptic seizures. Nat Med 24, 1638–1639 (2018). https://doi.org/10.1038/s41591-018-0249-6

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