Preconception cold–induced alterations of sperm DNA methylation result in offspring with altered brown adipose tissue and improved adaptation to overnutrition and hypothermia.
References
Nilsson, E., Sadler-Riggleman, I. & Skinner, M. K. Environ. Epigenet. 4, dvy016 (2018).
Cubas, P., Vincent, C. & Coen, E. Nature 401, 157–161 (1999).
Waddington, C. H. Evolution 7, 118–126 (1953).
Roth, O. & Landis, S. H. Evol. Appl. 10, 514–528 (2017).
Lu, J. J., Tan, D. Y., Baskin, C. C. & Baskin, J. M. Sci. Rep. 6, 25076 (2016).
Kreß, A., Oppold, A. M., Kuch, U., Oehlmann, J. & Müller, R. J. Insect Physiol. 99, 113–121 (2017).
Sun, W. et al. Nat. Med. https://doi.org/10.1038/s41591-018-0102-y (2018).
Symonds, M. E. et al. J. Endocrinol. 238, R53–R62 (2018).
Hales, C. N. & Barker, D. J. Br. Med. Bull. 60, 5–20 (2001).
Fullston, T. et al. FASEB J. 27, 4226–4243 (2013).
Skinner, M. K. Genome Biol. Evol. 7, 1296–1302 (2015).
Acknowledgements
I thank H. Johnson for assistance in preparation of this manuscript. This work was supported by grants from the National Institutes of Health (NIH; ES012974) and the John Templeton Foundation (50183) to M.K.S.
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Skinner, M.K. Preconception cold–induced epigenetic inheritance. Nat Med 24, 1308–1309 (2018). https://doi.org/10.1038/s41591-018-0187-3
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DOI: https://doi.org/10.1038/s41591-018-0187-3
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