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Gene therapy

A path to efficient gene editing

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Signaling by the tumor-suppressor protein p53 antagonizes CRISPR–Cas9 gene editing of human pluripotent stem cells and immortalized human retinal pigment epithelial cells.

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Fig. 1: Induction of p53 contributes to inefficient gene editing in hPSCs.

Marina Spence/Springer Nature

References

  1. Urnov, F. D. CRISPR J. 1, 34–46 (2018).

    Article  Google Scholar 

  2. Doudna, J. A. & Charpentier, E. Science 346, 1258096–1258096 (2014).

    Article  PubMed  CAS  Google Scholar 

  3. Hockemeyer, D. & Jaenisch, R. Cell Stem Cell 18, 573–586 (2016).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  4. Ihry, R. J. et al. Nat. Med. https://doi.org/10.1038/s41591-018-0050-6 (2018).

  5. Haapaniemi, E. et al. Nat. Med. https://doi.org/10.1038/s41591-018-0049-z (2018).

  6. Meyers, R. M. et al. Nat. Genet. 49, 1779–1784 (2017).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. Tebas, P. et al. N. Engl. J. Med. 370, 901–910 (2014).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  8. Qasim, W. et al. Sci. Transl. Med. 9, eaaj2013 (2017).

    Article  PubMed  Google Scholar 

  9. Urnov, F. D. Curr. Opin. Genet. Dev. 52, 48–56 (2018).

    Article  PubMed  CAS  Google Scholar 

  10. Schwartz, S. D. et al. Lancet 385, 509–516 (2015).

    Article  PubMed  Google Scholar 

  11. da Cruz, L. et al. Nat. Biotechnol. 36, 328–337 (2018).

    Article  PubMed  CAS  Google Scholar 

  12. Dunbar, C. E. et al. Science 359, eaan4672 (2018).

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Fyodor D. Urnov.

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Urnov, F.D. A path to efficient gene editing. Nat Med 24, 899–900 (2018). https://doi.org/10.1038/s41591-018-0110-y

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