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IMMUNOTHERAPY

Modeling cytokine release syndrome

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Complete leukemic responses to chimeric antigen receptor–modified T cells are invariably accompanied by severe toxicity. Recently developed animal models allow mechanistic dissection and prevention of toxicity without loss of therapeutic benefit.

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Fig. 1: Modeling CRS after CAR T cell transfer in mice reveals macrophages to be key players in the development of CRS and neurotoxicity.

References

  1. Schmiegelow, K. et al. Lancet Oncol. 17, e231–e239 (2016).

    Article  PubMed  Google Scholar 

  2. Porter, D., Frey, N., Wood, P. A., Weng, Y. & Grupp, S. A. J. Hematol. Oncol. 11, 35 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Turtle, C. J. et al. Sci. Transl. Med. 8, 355ra116 (2016).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  4. Gust, J. et al. Cancer Discov. 7, 1404–1419 (2017).

    Article  PubMed  CAS  Google Scholar 

  5. Morgan, R. A. Mol. Ther. 20, 882–884 (2012).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  6. Norelli, M., et al. Nat. Med. https://doi.org/10.1038/s41591-018-0036-4 (2018).

  7. Giavridis, T., et al. Nat. Med. https://doi.org/10.1038/s41591-018-0041-7 (2018).

  8. Bedoya, F., Frigault, M. J. & Maus, M. V. Mol. Ther. 25, 314–320 (2017).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  9. Shultz, L. D. et al. J. Immunol. 154, 180–191 (1995).

    PubMed  CAS  Google Scholar 

  10. Hay, K. A. et al. Blood 130, 2295–2306 (2017).

    Article  PubMed  CAS  Google Scholar 

  11. Shum, T. et al. Cancer Discov. 7, 1238–1247 (2017).

    Article  PubMed  CAS  Google Scholar 

  12. Cruz, C. R. et al. Cytotherapy 12, 743–749 (2010).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Correspondence to Cliona Rooney.

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Rooney, C., Sauer, T. Modeling cytokine release syndrome. Nat Med 24, 705–706 (2018). https://doi.org/10.1038/s41591-018-0068-9

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