Complete leukemic responses to chimeric antigen receptor–modified T cells are invariably accompanied by severe toxicity. Recently developed animal models allow mechanistic dissection and prevention of toxicity without loss of therapeutic benefit.
References
Schmiegelow, K. et al. Lancet Oncol. 17, e231–e239 (2016).
Porter, D., Frey, N., Wood, P. A., Weng, Y. & Grupp, S. A. J. Hematol. Oncol. 11, 35 (2018).
Turtle, C. J. et al. Sci. Transl. Med. 8, 355ra116 (2016).
Gust, J. et al. Cancer Discov. 7, 1404–1419 (2017).
Morgan, R. A. Mol. Ther. 20, 882–884 (2012).
Norelli, M., et al. Nat. Med. https://doi.org/10.1038/s41591-018-0036-4 (2018).
Giavridis, T., et al. Nat. Med. https://doi.org/10.1038/s41591-018-0041-7 (2018).
Bedoya, F., Frigault, M. J. & Maus, M. V. Mol. Ther. 25, 314–320 (2017).
Shultz, L. D. et al. J. Immunol. 154, 180–191 (1995).
Hay, K. A. et al. Blood 130, 2295–2306 (2017).
Shum, T. et al. Cancer Discov. 7, 1238–1247 (2017).
Cruz, C. R. et al. Cytotherapy 12, 743–749 (2010).
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Rooney, C., Sauer, T. Modeling cytokine release syndrome. Nat Med 24, 705–706 (2018). https://doi.org/10.1038/s41591-018-0068-9
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DOI: https://doi.org/10.1038/s41591-018-0068-9
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