The effectiveness of pneumococcal vaccines declines with age for unknown reasons. We studied the responses of older adults to the 23-valent PPSV23 and the 13-valent PCV13, identifying distinct baseline immune characteristics associated with vaccine responsiveness, including a cytotoxicity signature associated with weaker responses to PCV13.
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References
Huang, S. S. et al. Healthcare utilization and cost of pneumococcal disease in the United States. Vaccine 29, 3398–3412 (2011). A study that presents data from the US healthcare system on pneumococcal disease burden.
Jackson, L. A. & Janoff, E. N. Pneumococcal Vaccination of Elderly Adults: New Paradigms for Protection. Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am. 47, 1328–1338 (2008). This review article analyses the impact of anti-pneumococcal vaccination in older individuals.
Pallmer, K. & Oxenius, A. Recognition and regulation of T cells by NK cells. Front. Immunol. 7, 251 (2016). A review article that presents the immunoregulatory effects of NK cells on adaptive immunity.
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This is a summary of: Ravichandran, S. et al. Distinct baseline immune characteristics associated with responses to conjugated and unconjugated pneumococcal polysaccharide vaccines in older adults. Nat. Immunol. https://doi.org/10.1038/s41590-023-01717-5 (2024).
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Baseline immune characteristics linked to pneumococcal vaccine responsiveness in older adults. Nat Immunol 25, 198–199 (2024). https://doi.org/10.1038/s41590-023-01737-1
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DOI: https://doi.org/10.1038/s41590-023-01737-1
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