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When ceramides meet immune senescence, a GIMAP5 connection

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Apart from lifestyle, environment and chance events, genetic factors have a key role in delineating the health and longevity of an individual. Research by Park et al. has now shed light on the role of mammalian GIMAP5, a longevity-assurance (LASS) gene encoding a GTP-binding protein that regulates ceramide synthesis and cellular senescence.

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Fig. 1: Mechanism of action of GIMAP5 and opportunity to pharmacologically correct its deficiency.

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Acknowledgements

C.M. is supported by a British Heart Foundation Senior Basic Science Research Fellowship (FS/SBSRF/22/31031[CM1]).

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  1. Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

    Atrayee Gope & Claudio Mauro

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  1. Atrayee Gope
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  2. Claudio Mauro
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Correspondence to Claudio Mauro.

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The authors declare no competing interests.

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Gope, A., Mauro, C. When ceramides meet immune senescence, a GIMAP5 connection. Nat Immunol 25, 196–197 (2024). https://doi.org/10.1038/s41590-023-01736-2

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