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Cancer immunology

CAR macrophages on a fast track to solid tumor therapy

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Expressing chimeric antigen receptors (CARs) in macrophages has led to promising results in preclinical and clinical work. Now, induced pluripotent stem cells have been combined with a second-generation CAR to achieve macrophage rewiring and to broaden the applicability of the approach to solid malignancies.

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Fig. 1: Human iPS cell-derived macrophages with a second-generation CAR.

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Acknowledgements

N.L. is supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy (EXC 2155; project number 390874280 and DFG support LA 3680/9-1); the REBIRTH Research Center for Translational Regenerative Medicine ‘Förderung aus Mitteln des Niedersächsischen Vorab’ (grant ZN3340); the European Research Council (ERC) under the European Union (EU)’s Horizon 2020 research and innovation program (grant agreement 852178); and the EU (grant agreement 101100859). The views and opinions expressed are, however, those of the authors only and do not necessarily reflect those of the EU or the ERC. Neither the EU nor the granting authority can be held responsible for them.

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Authors and Affiliations

  1. Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany

    Shifaa M. Abdin, Daniela Paasch & Nico Lachmann

  2. Center for Translational and Regenerative Medicine, Hannover Medical School, Hannover, Germany

    Shifaa M. Abdin, Daniela Paasch & Nico Lachmann

  3. RESIST, Cluster of Excellence, Hannover Medical School, Hannover, Germany

    Nico Lachmann

  4. Biomedical Research in End Stage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany

    Nico Lachmann

  5. Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany

    Nico Lachmann

Authors
  1. Shifaa M. Abdin
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  2. Daniela Paasch
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  3. Nico Lachmann
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Correspondence to Nico Lachmann.

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Competing interests

N.L. declares a patent application on the generation of human iPS cell-derived macrophages (IP PCT/EP2018/061574). The other authors declare no competing interests.

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Abdin, S.M., Paasch, D. & Lachmann, N. CAR macrophages on a fast track to solid tumor therapy. Nat Immunol 25, 11–12 (2024). https://doi.org/10.1038/s41590-023-01696-7

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  • DOI: https://doi.org/10.1038/s41590-023-01696-7

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