The use of T cell receptor signatures to track activated spike-specific T cell dynamics between recovery from SARS-CoV-2 infection and subsequent mRNA vaccination shows that vaccination effectively recruits pre-existing memory and new CD8+ T cell clonotypes.
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Acknowledgements
The authors are supported by an NHMRC fellowship (S.A.V.), theme-based research scheme of the research grants council (RGC) of HKSAR grant no. T11-705/21-N (S.A.V.), HKPF from the HKSAR RGC (C.A.C.).
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Rowntree, L.C., Cohen, C.A. & Valkenburg, S.A. Activation-based repertoire analysis for T cell clonal dynamics in hybrid COVID-19 immunity. Nat Immunol 25, 7–8 (2024). https://doi.org/10.1038/s41590-023-01695-8
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DOI: https://doi.org/10.1038/s41590-023-01695-8
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