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Gut Treg cells release IL-27 to regulate TH17 cell responses

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Interleukin-27 (IL-27) is a pleiotropic cytokine known for its diverse immune regulatory properties. Although innate immune cells are considered the major cellular sources of IL-27, we found that gut regulatory T cells (Treg cells) secrete IL-27 under inflammatory conditions, allowing them to selectively limit intestinal helper T17 cell (TH17 cell) responses in various disease settings.

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Fig. 1: Loss of Treg cell-derived IL-27 has context-dependent detrimental or beneficial outcomes.

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This is a summary of: Lin, C.-H. et al. Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of TH17 cell immunity. Nat. Immunol. https://doi.org/10.1038/s41590-023-01667-y (2023).

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Gut Treg cells release IL-27 to regulate TH17 cell responses. Nat Immunol 24, 1980–1981 (2023). https://doi.org/10.1038/s41590-023-01681-0

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  • DOI: https://doi.org/10.1038/s41590-023-01681-0

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