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Severe dengue progression beyond enhancement

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The immune response to dengue virus infection is a well-coordinated balancing act. New research shows that an imbalanced response — driven partially by the productive infection of antigen-presenting cells — is associated with progression to severe disease.

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Fig. 1: Direct viral infection of antigen-presenting cells may drive progression to severe dengue.

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Acknowledgements

The authors were supported by the Intramural Research Program at the National Institute of Allergy and Infectious Diseases.

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Authors and Affiliations

  1. Viral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA

    Camila D. Odio, Rosemary A. Aogo, Kelsey E. Lowman & Leah C. Katzelnick

  2. Laboratory of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK

    Kelsey E. Lowman

Authors
  1. Camila D. Odio
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  2. Rosemary A. Aogo
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  3. Kelsey E. Lowman
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  4. Leah C. Katzelnick
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Corresponding authors

Correspondence to Camila D. Odio or Leah C. Katzelnick.

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The authors declare no competing interests.

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Odio, C.D., Aogo, R.A., Lowman, K.E. et al. Severe dengue progression beyond enhancement. Nat Immunol 24, 1967–1969 (2023). https://doi.org/10.1038/s41590-023-01680-1

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