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A distinct subtype of stromal cell orchestrates the inflammatory response to tissue injury

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After acute injury to skeletal muscle, an ‘early responder’ subtype of stromal cells rapidly produces an array of inflammatory mediators. Disruption of this response causes abnormal accumulation of several adaptive lymphocyte populations, a prolongation of inflammation, and an effect on tissue regeneration.

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Fig. 1: Identification of an inflammatory MmSC subtype after acute injury.

References

  1. Wosczyna, M. N. et al. Mesenchymal stromal cells are required for regeneration and homeostatic maintenance of skeletal muscle. Cell Rep. 27, 2029–2035 (2019). This paper showed that ablation of MmSCs before acute injury led to a notable decrease in accumulation of CD45+ hematopoietic-lineage cells.

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This is a summary of: Yaghi, O. K. et al. A discrete ‘early-responder’ stromal-cell subtype orchestrates immunocyte recruitment to injured tissue. Nat. Immunol. https://doi.org/10.1038/s41590-023-01669-w (2023).

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A distinct subtype of stromal cell orchestrates the inflammatory response to tissue injury. Nat Immunol 24, 1976–1977 (2023). https://doi.org/10.1038/s41590-023-01670-3

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