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Gene-by-environment regulation of Kupffer cell transcriptomes and epigenomes

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Genetic and environmental diversity are major drivers of macrophage transcriptional responses, but the mechanisms that underlie the relative contributions of gene-by-environment interactions to transcriptional responses of tissue macrophages are unclear. We defined the relative effect of cis regulation, cell-autonomous trans regulation, and non-cell-autonomous trans regulation of Kupffer cell gene expression.

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Fig. 1: Cell-autonomous and non-cell-autonomous trans effects drive Kupffer cell gene expression.

References

  1. Cox, N. et al. Origins, biology, and diseases of tissue macrophages. Annu. Rev. Immunol. 39, 313–344 (2021). A review article that presents findings for tissue macrophages in diverse diseases.

    Article  CAS  PubMed  Google Scholar 

  2. Hindorff, L. A. et al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc. Natl Acad. Sci. USA 106, 9362–9367 (2009). This paper reports that trait-associated SNPs are significantly associated only with non-coding DNA regions.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Liu, X., Li, Y. I. & Pritchard, J. K. Trans effects on gene expression can drive omnigenic inheritance. Cell 177, 1022–1034.e6 (2019). This paper reports a theory that the summation of effects through trans-acting genetic variants might explain 70% of heritability.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Link, V. M. et al. Analysis of genetically diverse macrophages reveals local and domain-wide mechanisms that control transcription factor binding and function. Cell 173, 1796–1809.e17 (2018). This paper reports on transcriptional mechanisms in genetically diverse macrophages.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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This is a summary of: Bennett, H. et al. Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes. Nat. Immunol. https://doi.org/10.1038/s41590-023-01631-w (2023).

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Gene-by-environment regulation of Kupffer cell transcriptomes and epigenomes. Nat Immunol 24, 1797–1798 (2023). https://doi.org/10.1038/s41590-023-01643-6

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  • DOI: https://doi.org/10.1038/s41590-023-01643-6

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