Current acellular pertussis vaccines prevent disease but do not prevent nasal infection and transmission of Bordetella pertussis. However, immunology is helping to design new vaccines that induce sterilizing immunity.
References
Warfel, J. M., Zimmerman, L. I. & Merkel, T. J. Proc. Natl Acad. Sci. USA 111, 787–792 (2014).
Wilk, M. M. et al. Emerg. Microbes Infect. 8, 169–185 (2019).
da Silva Antunes, R. et al. J. Clin. Invest. 128, 3853–3865 (2018).
Allen, A. C. et al. Mucosal Immunol. 11, 1763–1776 (2018).
Solans, L. et al. Mucosal Immunol. 11, 1753–1762 (2018).
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The author is an inventor on a patent around a new pertussis vaccine and receives research funding from and consults for vaccine manufacturers.
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Mills, K.H.G. How immunology can help reverse the pertussis vaccine failure. Nat Immunol 24, 1779–1780 (2023). https://doi.org/10.1038/s41590-023-01625-8
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DOI: https://doi.org/10.1038/s41590-023-01625-8
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