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Neuroimmunology

CD8+ T cells pump the brakes on Alzheimer’s disease

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A recent study identified a microglia–T cell communication axis that retains CD8+ T cells in brains with amyloid pathology. Data from this study indicate that CD8+ T cells restrict Alzheimer’s disease pathogenesis.

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Fig. 1: Balance of inflammatory and immunosuppressive T cells in Alzheimer’s disease.

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Authors and Affiliations

  1. Department of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC, USA

    Katie L. Reagin & Kristen E. Funk

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  1. Katie L. Reagin
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  2. Kristen E. Funk
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Correspondence to Kristen E. Funk.

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The authors declare no competing interests.

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Reagin, K.L., Funk, K.E. CD8+ T cells pump the brakes on Alzheimer’s disease. Nat Immunol 24, 1597–1598 (2023). https://doi.org/10.1038/s41590-023-01622-x

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