Skip to main content

Advertisement

Log in

The role of recruitment versus training in influenza-induced lasting changes to alveolar macrophage function

  • Matters Arising
  • Published:

From Nature Immunology

View current issue Submit your manuscript

Matters Arising to this article was published on 28 August 2023

The Original Article was published on 20 February 2023

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1: Recruitment versus training of the alveolar macrophage compartment.

References

  1. Wang, T. et al. Influenza-trained mucosal-resident alveolar macrophages confer long-term antitumor immunity in the lungs. Nat. Immunol. 24, 423–438 (2023).

    Article  CAS  PubMed  Google Scholar 

  2. Li, F. et al. Monocyte-derived alveolar macrophages autonomously determine severe outcome of respiratory viral infection. Sci. Immunol. 7, eabj5761 (2022).

    Article  CAS  PubMed  Google Scholar 

  3. Aegerter, H. et al. Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection. Nat. Immunol. 21, 145–157 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Machiels, B. et al. A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes. Nat. Immunol. 18, 1310–1320 (2017).

    Article  CAS  PubMed  Google Scholar 

  5. Yao, Y. et al. Induction of autonomous memory alveolar macrophages requires T cell help and is critical to trained immunity. Cell 175, 1634–1650 (2018).

    Article  CAS  PubMed  Google Scholar 

  6. Netea, M. G., Quintin, J. & Van Der Meer, J. W. M. Trained immunity: a memory for innate host defense. Cell Host Microbe 9, 355–361 (2011).

    Article  CAS  PubMed  Google Scholar 

  7. Ginhoux, F. & Guilliams, M. Tissue-resident macrophage ontogeny and homeostasis. Immunity 44, 439–449 (2016).

    Article  CAS  PubMed  Google Scholar 

  8. Guilliams, M. et al. Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF. J. Exp. Med. 210, 1977–1992 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. van de Laar, L. et al. Yolk sac macrophages, fetal liver, and adult monocytes can colonize an empty niche and develop into functional tissue-resident macrophages. Immunity 44, 755–768 (2016).

    Article  PubMed  Google Scholar 

  10. Kulikauskaite, J. & Wack, A. Teaching old dogs new tricks? The plasticity of lung alveolar macrophage subsets. Trends Immunol. 41, 864–877 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Hermesh, T., Moltedo, B., Moran, T. M. & López, C. B. Antiviral instruction of bone marrow leukocytes during respiratory viral infections. Cell Host Microbe 7, 343–353 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Aegerter, H., Lambrecht, B. N. & Jakubzick, C. V. Biology of lung macrophages in health and disease. Immunity 55, 1564–1580 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Gibbings, S. L. et al. Transcriptome analysis highlights the conserved difference between embryonic and postnatal-derived alveolar macrophages. Blood 126, 1357–1366 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Misharin, A. V. et al. Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span. J. Exp. Med. 214, 2387–2404 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Serbina, N. V. & Pamer, E. G. Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2. Nat. Immunol. 7, 311–317 (2006).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Contributions

C.S.I. and A.W. wrote the manuscript. J.K., H.A., F.L., F.P., C.V.J., M.G. and M.K. contributed conceptionally and helped to edit the text.

Corresponding author

Correspondence to Andreas Wack.

Ethics declarations

Competing interests

The authors declare no competing interests.

Peer review

Peer review information

Nature Immunology thanks Maziar Divangahi and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. Primary Handling Editor: N. Bernard, in collaboration with the Nature Immunology team.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Iliakis, C.S., Kulikauskaite, J., Aegerter, H. et al. The role of recruitment versus training in influenza-induced lasting changes to alveolar macrophage function. Nat Immunol 24, 1639–1641 (2023). https://doi.org/10.1038/s41590-023-01602-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-023-01602-1

  • Springer Nature America, Inc.

This article is cited by

Navigation