Skip to main content
SpringerLink
Log in

EGR2 drives TH17 cell pathogenicity in autoimmune neuroinflammation

  • Research Briefing
  • Published:

From Nature Immunology

View current issue Submit your manuscript

The mechanisms by which TH17 cells can either protect barrier tissues or initiate autoimmunity remain unknown. Here we identify the transcription factor EGR2 as a key determinant of TH17 cell pathogenicity. EGR2 was found to govern TH17 cell migration, regulate the expression of pathogenicity-associated genes, and facilitate the recruitment of other immune cells in the central nervous system.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Pathogenic CD4+ T cell responses in MS are associated with upregulation of EGR transcription factors.

References

  1. Mills, K. H. G. IL-17 and IL-17-producing cells in protection versus pathology. Nat. Rev. Immunol. 23, 38–54 (2023). This review article discusses protective and pathogenic nature of TH17 cells.

    Article  CAS  PubMed  Google Scholar 

  2. Loo, T. T., Gao, Y. & Lazarevic, V. Transcriptional regulation of CD4+ TH cells that mediate tissue inflammation. J. Leukoc. Biol. 104, 1069–1085 (2018). This review discusses how combinatorial expression of transcription factors regulates CD4+ T cell function.

    Article  CAS  PubMed  Google Scholar 

  3. Cao, Y. et al. Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis. Sci. Transl. Med. 7, 287ra274 (2015). This paper reports that myelin-reactive T cells from patients with MS secrete more proinflammatory cytokines than cells from healthy controls.

    Article  Google Scholar 

  4. Gaublomme, J. T. et al. Single-cell genomics unveils critical regulators of TH17 cell pathogenicity. Cell 163, 1400–1412 (2015). This paper uses single-cell RNA-seq to identify regulators of TH17 cell pathogenicity.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Ciofani, M. et al. A validated regulatory network for TH17 cell specification. Cell 151, 289–303 (2012). This study reports the first comprehensive, validated gene regulatory network for TH17 cell lineage commitment.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Gao, Y. et al. Transcription factor EGR2 controls homing and pathogenicity of TH17 cells in the central nervous system. Nat. Immunol. https://doi.org/10.1038/s41590-023-01553-7 (2023).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

EGR2 drives TH17 cell pathogenicity in autoimmune neuroinflammation. Nat Immunol 24, 1230–1231 (2023). https://doi.org/10.1038/s41590-023-01568-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-023-01568-0

  • Springer Nature America, Inc.

Search

Navigation