Mechanisms that explain the hygiene hypothesis for allergy and asthma are unclear. A mouse model that cohouses ‘dirty’ pet-store mice with clean laboratory mice might help to understand this immunology.
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References
Strachan, D. P. Br. Med. J. 299, 1259–1260 (1989).
Shanahan, F. Clin. Exp. Immunol. 160, 92–97 (2010).
Sekirov, I., Russell, S. L., Antunes, L. C. & Finlay, B. B. Physiol. Rev. 90, 859–904 (2010).
Block, K. et al. Nat. Immunol. https://doi.org/10.1038/s41590-022-01350-8 (2022).
Beura, L. K. et al. Nature 532, 512–616 (2016).
Huggins, M. A. et al. Cell Rep. 28, 1729–1743 e5 (2019).
Von Ehrenstein, O. S. et al. Clin. Exp. Allergy 30, 187–193 (2000).
Kummeling, I. et al. Pediatrics 119, e225–e231 (2007).
Kero, J. et al. Pediatr. Res. 52, 6–11 (2002).
Feehley, T. et al. Nat. Med. 25, 448–453 (2019).
Abdel-Gadir, A. et al. Nat. Med. 25, 1164–1174 (2019).
Fujimura, K. E. et al. Proc. Natl Acad. Sci. 111, 805–810 (2014).
Atarashi, K. et al. Science 331, 337–341 (2011).
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Umetsu, D.T. Understanding microorganisms in the prevention of allergy. Nat Immunol 23, 1657–1658 (2022). https://doi.org/10.1038/s41590-022-01356-2
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DOI: https://doi.org/10.1038/s41590-022-01356-2
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