DNSe, a double-negative thymocyte-specific Notch1 enhancer, is essential for activation of Notch1 expression and has a central role in T-cell-lineage commitment during the earliest stages of thymocyte development.
This is a preview of subscription content, log in via an institution to check access.
References
Kashiwagi, M. et al. Nat. Immunol. https://doi.org/10.1038/s41590-022-01322-y (2022).
Kidd, S., Kelley, M. R. & Young, M. W. Mol. Cell. Biol. 6, 3094–3108 (1986).
Wharton, K. A. et al. Cell 43, 567–581 (1985).
Taghon, T. et al. Immunity 24, 53–64 (2006).
Yashiro-Ohtani, Y. et al. Genes Dev. 23, 1665–1676 (2009).
Radtke, F. et al. Immunity 10, 547–558 (1999).
Pui, J. C. et al. Immunity 11, 299–308 (1999).
Gomez-del Arco, P. et al. Immunity 33, 685–698 (2010).
Weng, A. P. et al. Science 306, 269–271 (2004).
Assumpcao, A. et al. Development 148, dev197319 (2021).
Winandy, S., Wu, P. & Georgopoulos, K. Cell 83, 289–299 (1995).
Joshi, I. et al. Nat. Immunol. 15, 294–304 (2014).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Yamashita, M., Taniuchi, I. Fine-tuning Notch1 by the stage-specific enhancer. Nat Immunol 23, 1509–1511 (2022). https://doi.org/10.1038/s41590-022-01341-9
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41590-022-01341-9
- Springer Nature America, Inc.