CD40 has long been known as a co-stimulatory molecule involved in T cell help for dendritic cells, and thereby as a contributor to CD8+ T cell immunity against cancers and infections. However, CD40 signaling drives complex functional responses that can contribute to tumor-specific CD8+ T cell responses in unexpected ways.
This is a preview of subscription content, log in via an institution to check access.
References
Ardouin, L. et al. Immunity 45, 305–318 (2016).
Bedoui, S. et al. Immunol. Rev. 272, 52–64 (2016).
Wu, R. et al. Nat. Immunol. https://doi.org/10.1038/s41590-022-01324-w (2022).
Ferris, S. T. et al. Nature 584, 624–629 (2020).
Ahrends, T. et al. Immunity 47, 848–861 (2017).
Bevan, M. J. Nat. Rev. Immunol. 4, 595–602 (2004).
Roberts, E. W. et al. Cancer Cell 30, 324–336 (2016).
Busselaar, J. et al. Front. Immunol. 11, 592569 (2020).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Bedoui, S., Gebhardt, T. Unappreciated complexity in T cell help for dendritic cells. Nat Immunol 23, 1515–1516 (2022). https://doi.org/10.1038/s41590-022-01335-7
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41590-022-01335-7
- Springer Nature America, Inc.