Akin to adult stem cells, precursor exhausted T cells are hierarchically organized, with long-lived CD62L+ stem-like T cells at the apex of the system. The transcription factor c-Myb controls the formation, maintenance and therapeutic function of these cells, with important implications for their clinical utilization.
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References
Gattinoni, L. et al. Nat. Med. 17, 1290–1297 (2011).
Utzschneider, D. T. et al. Immunity 45, 415–427 (2016).
Im, S. J. et al. Nature 537, 417–421 (2016).
Tsui, C. et al. Nature https://doi.org/10.1038/s41586-022-05105-1 (2022).
Yao, C. et al. Nat. Immunol. 20, 890–901 (2019).
Dykstra, B. et al. Cell Stem Cell 1, 218–229 (2007).
Johnnidis, J. B. et al. Sci. Immunol. 6, eabe3702 (2021).
Gautam, S. et al. Nat. Immunol. 20, 337–349 (2019).
Pais Ferreira, D. et al. Immunity 53, 985–1000 e1011 (2020).
Bresser, K. et al. Nat. Immunol. 23, 791–801 (2022).
Galletti, G. et al. Nat. Immunol. 21, 1552–1562 (2020).
Chen, Z. et al. Cell Rep. 20, 2584–2597 (2017).
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L.G. is an inventor on a patent that describes methods for generating and isolating TSCM cells and on a patent that describes the use of c-Myb to enhance T cell therapy efficacy. L.G. has consulting agreements with Lyell Immunopharma, Advaxis Immunotherapies and Instil Bio, is on the scientific advisory boards of Poseida Therapeutics and Kiromic, and is a stockholder of Poseida Therapeutics. C.H. declares no competing interests.
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Heuser, C., Gattinoni, L. c-Myb redefines the hierarchy of stem-like T cells. Nat Immunol 23, 1405–1407 (2022). https://doi.org/10.1038/s41590-022-01319-7
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DOI: https://doi.org/10.1038/s41590-022-01319-7
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