Skip to main content
SpringerLink
Log in

Patrolling ILC3 cells monitor intestinal tissue in response to inflammation

  • Research Briefing
  • Published:

From Nature Immunology

View current issue Submit your manuscript

Intestinal group 3 innate lymphoid (ILC3) cells exhibit increased mobility in response to flagellin-mediated inflammation. This ‘patrolling’ behavior promotes IL-22 diffusion and prevents intestinal epithelial cell death. Enhanced ILC3 dynamics rely on environmental cues and suggest a prominent ILC3 tissue adaptation that reinforces intestinal barrier integrity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: ILC3 cells patrol intestinal villi.

References

  1. Caruso, R., Lo, B. C. & Núñez, G. Host–microbiota interactions in inflammatory bowel disease. Nat. Rev. Immunol. 20, 411–426 (2020). This review summarizes the complex interactions between intestinal microorganisms and the intestinal barrier.

    Article  CAS  Google Scholar 

  2. Serafini, N., Vosshenrich, C. A. J. & Di Santo, J. P. Transcriptional regulation of innate lymphoid cell fate. Nat. Rev. Immunol. 15, 415–428 (2015). This review summarizes the heterogeneity of innate lymphoid cells and their development.

    Article  CAS  Google Scholar 

  3. Klose, C. S. N. & Artis, D. Innate lymphoid cells control signaling circuits to regulate tissue-specific immunity. Cell Res. 30, 475–491 (2020). This review summarizes the emerging roles of innate lymphoid cells in tissue homeostasis and inflammation.

    Article  Google Scholar 

  4. Serafini, N. et al. Trained ILC3 responses promote intestinal defense. Science 375, 859–863 (2022). This article describes the role of ILC3 cells after pathogen rechallenge and the existence of memory ILC3 cells.

    Article  CAS  Google Scholar 

  5. Satoh-Takayama, N. et al. The chemokine receptor CXCR6 controls the functional topography of interleukin-22 producing intestinal innate lymphoid cells. Immunity 41, 776–788 (2014). This article describes the importance of the topography of intestinal ILC3 cells for mucosal defense.

    Article  CAS  Google Scholar 

Download references

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Jarade, A. et al. Inflammation triggers ILC3 patrolling of the intestinal barrier. Nat. Immunol. https://doi.org/10.1038/s41590-022-01284-1 (2022).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Patrolling ILC3 cells monitor intestinal tissue in response to inflammation. Nat Immunol 23, 1305–1306 (2022). https://doi.org/10.1038/s41590-022-01299-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-022-01299-8

  • Springer Nature America, Inc.

Search

Navigation