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The systemic effect of type 1 interferon responsiveness on tumor immunotherapy

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Immune checkpoint blocking therapies do not always work and come with some risks, but identifying non-responders and patients at risk of adverse events is becoming easier and more accurate.

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Fig. 1: Workflow for defining the outcome of PD-1 blockade therapy on T cell responsiveness to type I IFNs.

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Authors and Affiliations

  1. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

    Shicheng Su & Erwei Song

  2. Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

    Shicheng Su & Erwei Song

Authors
  1. Shicheng Su
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  2. Erwei Song
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Correspondence to Erwei Song.

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The authors declare no competing interests.

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Su, S., Song, E. The systemic effect of type 1 interferon responsiveness on tumor immunotherapy. Nat Immunol 23, 1141–1143 (2022). https://doi.org/10.1038/s41590-022-01275-2

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