Skip to main content
SpringerLink
Log in

CANCER IMMUNOLOGY

Deciphering immunoregulatory vulnerabilities in human cancers

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

Regulatory T cells that express high levels of IL-1R and ICOS display transcriptional features of antigen specificity, are highly suppressive and distinguish tumors from non-malignant inflamed tissues

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: A translational pipeline for the identification of immunoregulatory targets in tumor samples and matched non-malignant inflamed tissues.

References

  1. Martins, F. et al. Nat. Rev. Clin. Oncol. 16, 563–580 (2019).

    Article  CAS  PubMed  Google Scholar 

  2. Mair, F. et al. Nature 605, 728–735 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Greene, E. et al. Patterns (N Y) 2, 100372 (2021).

    Article  CAS  PubMed  Google Scholar 

  4. Browaeys, R., Saelens, W. & Saeys, Y. Nat. Methods 17, 159–162 (2020).

    Article  CAS  PubMed  Google Scholar 

  5. Ahmadzadeh, M. et al. Sci. Immunol. https://doi.org/10.1126/sciimmunol.aao4310 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Jain, A., Song, R., Wakeland, E. K. & Pasare, C. Nat. Commun. 9, 3185 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Fu, T., He, Q. & Sharma, P. Cancer Res. 71, 5445–5454 (2011).

    Article  CAS  PubMed  Google Scholar 

  8. Simpson, T. R. et al. J. Exp. Med. 210, 1695–1710 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Solomon, I. et al. Nat. Can. 1, 1153–1166 (2020).

    Article  CAS  Google Scholar 

  10. Kidani, Y. et al. Proc. Natl Acad. Sci. USA 119, e2114282119 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK

    Felipe Gálvez-Cancino & Sergio A. Quezada

  2. Centro Cientifico y Tecnologico de Excelencia Ciencia & Vida, Fundacion Ciencia & Vida, Santiago, Chile

    Alvaro Lladser

  3. Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, Chile

    Alvaro Lladser

Authors
  1. Felipe Gálvez-Cancino
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alvaro Lladser
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sergio A. Quezada
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Alvaro Lladser or Sergio A. Quezada.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gálvez-Cancino, F., Lladser, A. & Quezada, S.A. Deciphering immunoregulatory vulnerabilities in human cancers. Nat Immunol 23, 995–996 (2022). https://doi.org/10.1038/s41590-022-01251-w

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-022-01251-w

  • Springer Nature America, Inc.

Search

Navigation