Skip to main content
SpringerLink
Log in

Defining an exhaustion-like program that restrains autoreactive CD8+ T cells

  • Research Briefing
  • Published:

From Nature Immunology

View current issue Submit your manuscript

Intra-islet CD8+ T cells from a mouse model of type 1 diabetes exhibit an exhausted phenotype that differs from the canonical T cell exhaustion observed in cancer and chronic viral infection. Deletion of the inhibitory receptor LAG3 in these cells accelerated diabetes incidence and partially reversed this restrained phenotype.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: The phenotype of intra-islet CD8+ T cells.

References

  1. Blank, C. U. et al. Defining 'T cell exhaustion'. Nat. Rev. Immunol. 19, 665–674 (2019). A comprehensive review summarizing almost 30 years of research into the developmental state of T cell exhaustion.

    Article  CAS  PubMed  Google Scholar 

  2. Grebinoski, S. & Vignali, D. A. A. Inhibitory receptor agonists: the future of autoimmune disease therapeutics? Curr. Opin. Immunol. 67, 1–9 (2020). A comprehensive review examining the current and future state of the development of immunotherapeutic IR agonists to treat autoimmune diseases, and the evidence supporting these efforts.

    Article  CAS  PubMed  Google Scholar 

  3. Bettini, M. et al. Cutting edge: accelerated autoimmune diabetes in the absence of LAG-3. J. Immunol. 187, 3493–3498 (2011). A research article that first sparked our interest in studying the role of LAG3 in limiting autoimmune diabetes.

    Article  CAS  PubMed  Google Scholar 

  4. Zhang, Q. et al. LAG3 limits regulatory T cell proliferation and function in autoimmune diabetes. Sci. Immunol. 2, eaah4569 (2017). A research article investigating the role of LAG3 in limiting regulatory T cell function in autoimmune diabetes.

    Article  PubMed  Google Scholar 

  5. Chen, Y.-G., Mathews, C. E. & Driver, J. P. The role of NOD mice in type 1 diabetes research: lessons from the past and recommendations for the future. Front. Endocrinol. https://doi.org/10.3389/fendo.2018.00051 (2018). A comprehensive review of the NOD mouse model of autoimmune diabetes and how it is used to enhance the understanding of T1D.

    Article  Google Scholar 

Download references

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Grebinoski, S. et al. Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3. Nat. Immunol. https://doi.org/10.1038/s41590-022-01210-5 (2022).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Defining an exhaustion-like program that restrains autoreactive CD8+ T cells. Nat Immunol 23, 832–833 (2022). https://doi.org/10.1038/s41590-022-01211-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-022-01211-4

  • Springer Nature America, Inc.

Search

Navigation