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LAG3 disrupts the TCR signal by local acidification

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LAG3 interferes with TCR signaling by lowering the pH in the vicinity of the TCR and inducing dissociation of the key signaling kinase Lck from the co-receptors CD8 and CD4.

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Fig. 1: Schematic representation of the inhibitory effects of LAG3.

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  1. Institut Curie, PSL University, Inserm U932, Immunity and Cancer, Paris, France

    Claire Hivroz

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  1. Claire Hivroz
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Correspondence to Claire Hivroz.

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Hivroz, C. LAG3 disrupts the TCR signal by local acidification. Nat Immunol 23, 649–651 (2022). https://doi.org/10.1038/s41590-022-01196-0

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