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T cell memories of past divisions

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A genetic recorder of T cell replicative history identifies fewer accumulated divisions in a subset of CD8+ central memory T cells that shows stem-cell-like quiescence and superior recall capacity.

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Fig. 1: Hypothetical relation of T cell replicative history and T cell fate decisions during the expansion, memory and recall phases of an adaptive immune response.

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Acknowledgements

This work was supported by the European Research Council starting grant 949719-SCIMAP and the Else Kröner-Fresenius-Stiftung grant EKFS 2019_A91 to V.R.B.

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Authors and Affiliations

  1. Technical University of Munich, School of Medicine, Institute for Medical Microbiology, Immunology and Hygiene, Munich, Germany

    Lorenz Kretschmer & Veit R. Buchholz

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  1. Lorenz Kretschmer
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  2. Veit R. Buchholz
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Correspondence to Veit R. Buchholz.

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The authors declare no competing interests.

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Kretschmer, L., Buchholz, V.R. T cell memories of past divisions. Nat Immunol 23, 646–647 (2022). https://doi.org/10.1038/s41590-022-01193-3

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