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γδ T cells monitor tissue health

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Crosstalk between the dendritic epidermal γδ T cell (DETC) T cell receptor and Skint1 expressed by keratinocytes at steady state regulates epidermal barrier function and maintains DETC responsiveness.

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Fig. 1: Epidermal Skint1–DETC interactions maintain immunosurveillance and barrier function.

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Authors and Affiliations

  1. Department of Pathology, Department of Medicine, Ronald O. Perelman Department of Dermatology, and Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA

    Ipsita Subudhi & Shruti Naik

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  1. Ipsita Subudhi
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  2. Shruti Naik
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Correspondence to Shruti Naik.

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The authors declare no competing interests.

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Subudhi, I., Naik, S. γδ T cells monitor tissue health. Nat Immunol 23, 348–349 (2022). https://doi.org/10.1038/s41590-022-01139-9

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